TATA-Binding Protein



TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, i.e. the crystal structure of yeast TATA-binding protein (1tbp).

TBP
2z8u – TBP – Methanococcus janaschii

1pcz – PwTBP - Pyrococcus woesei

1vok – AtTBP - Arabidopsis thaliana

1tbp – yTBP - yeast

1mp9 – TBP – Sulfolobus acidocaldarius

TBP+DNA TATA
1ytb - yTBP + DNA TATA

1cdw - hTBP core domain+ DNA TATA - human

1tgh - hTBP + DNA TATA

1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4 - AtTBP + DNA TATA

TBP+DNA TATA+TFIIA
1rm1 – yTBP+TFIIA α, β, γ chains+ DNA TATA

1ytf - yTBP+TFIIA + DNA TATA

1nh2 – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA

1nvp - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA

1jfi - hTBP C-terminal+ TFIIA NC2+ DNA TATA

TBP+DNA TATA+TFIIB
1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA

1tba – yTBP core domain+TAFII230 fragment - NMR

1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter

1vol – AtTBP+hTFIIB+DNA TATA

1ais, 1d3u - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA

1tba – yTBP core domain+TAFII230 fragment - NMR

Additional information
See: Transcription for additional Proteopedia resources

This page has some initial scenes, but could use expansion and creation of new scenes. 

called the  TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif

interact with the phosphate groups

 phenylalanine amino acids

 asparagine amino acids

two symmetrical halves.